Cramer Lab - Publications

Publications

Highlights

(For a full list go to Google Scholar)

Molecular Simulations of Multimodal Ligand-Protein Binding: Elucidation of Binding Sites and Correlation with Experiments

Freed, AS, Garde S, Cramer SM

J. Phys. Chem. B 2011, 115, 45, 13320-13327

Investigation of protein binding affinity and preferred orientations in ion exchange systems using a homologous protein library

Chung, W.K., Hou, Y., Freed, A, Holstein, M., Makhatadze, G., and Cramer, S.M.

Biotechnol. Bioeng., 102, 869-881

Latest…

Development of phage biopanning strategies to identify affinity peptide ligands for kappa light chain Fab fragments.
Nascimento, A., Mullerpatan, A., Azevedo, A.M., Karande, P., Cramer, S.M.
Biotechnol Progress., e2884, (2019)

Design of peptide ligands for affinity purification of human growth hormone.
Chandra, D., Timmick, S., Goodwine, C., Vecchiarello, N., Shastry, D.G., Mullerpatan, A., Trasatti, J.P., Cramer, S.M., Karande, P.
J. Chem. Technol. Biotechnol., 94, 2345-2354, (2019)

Investigation of cathepsin D-mAb interactions using a combined experimental and computational tool set.
Ranjan, S., Chung, W.K., Hofele, R., Thompson, J.H., Bee, J., Zhang, L., Robbins, D., Cramer, S.M.
Biotechnology and Bioengineering., 116, 1684-1697, (2019)

Conformational Equilibria of Multimodal Chromatography Ligands in Water and Bound to Protein Surfaces.
Bilodeau, C.L., Lau, E.Y., Cramer, S.M., Garde, S.
J. Phys. Chem. B., 123, 23, 4833-4843, (2019)

Mechanistic modeling based process development for monoclonal antibody monomer-aggregate separations in multimodal cation exchange chromatography.
Zhang, L., Parasnavis, S., Zhengjian, L., Chen, J., Cramer, S.M.
J. Chromatogr. A., 1602, 317-325, (2019)

A combined screening and in silico strategy for the rapiddesign of integrated downstream processes for process and product-related impurity removal.
Vecchiarello, N., Timmick, S.M., Goodwine, C., Crowell, L.E., Love, J.C., Cramer, S.M.
Biotechnology and Bioengineering., 116, 2178-2190, (2019)

Implementation of an experimental and computational tool set to study protein-mAb interactions.
Ranjan, S., Chung, W.K., Zhu, M., Robbins, D., Cramer, S.M.
Biotechnol. Progress., 35:e2825, (2019)

Investigating the impact of aromatic ring substitutions on selectivity for a multimodal anion exchange prototype library.
Robinson, J., Snyder, M.A., Belisle, C., Liao, J., Chen, H., He, X., Xu, Y., Cramer, S.M.
J. Chromatogr. A., 1569, 101-109, (2018)

Domain contributions to antibody retention in multimodal chromatography systems.
Robinson, J., Roush, D., Cramer, S.M.
J. Chromatogr. A., 1563, 89-98, (2018)

Rational Design of Peptide Affinity Ligands for the Purification of Therapeutic Enzymes.
Trasatti, J.P., Woo, J., Ladiwala, A, Cramer, S.M., Karande, P.
Biotechnol. Prog., 34, 987-998, (2018)